An Overview of Obesity, Cholesterol, and Systemic Inflammation in Preeclampsia

Author:

Alston Morgan C.,Redman Leanne M.ORCID,Sones Jennifer L.

Abstract

Preeclampsia (PE), an inflammatory state during pregnancy, is a significant cause of maternal and fetal morbidity and mortality. Adverse outcomes associated with PE include hypertension, proteinuria, uterine/placental abnormalities, fetal growth restriction, and pre-term birth. Women with obesity have an increased risk of developing PE likely due to impaired placental development from altered metabolic homeostasis. Inflammatory cytokines from maternal adipose tissue and circulating cholesterol have been linked to systemic inflammation, hypertension, and other adverse outcomes associated with PE. This review will summarize the current knowledge on the role of nutrients, obesity, and cholesterol signaling in PE with an emphasis on findings from preclinical models.

Funder

National Institutes of Health

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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