Natural Ingredients to Improve Immunity
-
Published:2023-04-01
Issue:4
Volume:16
Page:528
-
ISSN:1424-8247
-
Container-title:Pharmaceuticals
-
language:en
-
Short-container-title:Pharmaceuticals
Author:
Gasmi Amin1ORCID, Shanaida Mariia2ORCID, Oleshchuk Oleksandra2ORCID, Semenova Yuliya3ORCID, Mujawdiya Pavan Kumar4, Ivankiv Yana2, Pokryshko Olena2ORCID, Noor Sadaf5, Piscopo Salva16, Adamiv Stepan7, Bjørklund Geir8ORCID
Affiliation:
1. Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, 69100 Villeurbanne, France 2. I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine 3. School of Medicine, Nazarbayev University, 5/1 Kerey and Zhanibek Khandar Str., Astana 010000, Kazakhstan 4. Inochi Care Private Limited, New Delhi 110017, India 5. Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Multan 60000, Pakistan 6. Department of Nutritional Research and Development, Nutri-Logics SA, 9990 Luxembourg, Luxembourg 7. Department of General Dentistry, Odessa National Medical University, 65000 Odessa, Ukraine 8. Council for Nutritional and Environmental Medicine, 8610 Mo i Rana, Norway
Abstract
The immune system protects the body from infectious agents such as bacteria, viruses, or fungi. Once encountered with pathogens or antigens, the innate and adaptive arms of the immune system trigger a strong immune response to eliminate them from the system and protect the body. Thus, well-balanced immunity is pivotal for maintaining human health, as an insufficient level of immune defense leads to infections and tumors. In contrast, the excessive functioning of the immune system causes the development of autoimmune diseases and allergies. Strong immunity requires adequate nutrition, dietary interventions, and sufficient intake of certain vitamins (vitamin C, vitamin D, and folic acid) and minerals (magnesium, zinc, and selenium). Therefore, nutritional and micronutrient deficiencies lead to compromised immunity. Several natural ingredients have shown potent immunomodulatory properties. The immune-enhancing properties of many plants and fungi are due to containing bioactive phytoconstituents such as polyphenols, terpenoids, β-glucans, vitamins, etc. Probiotics and prebiotics can be used as innovative tools to reduce intestinal inflammation and downregulate hypersensitivity reactions. Plant sources of melatonin, a multifunctional molecule with proven anti-inflammatory and immunomodulatory properties, have been discovered relatively recently. The bioactive compounds augment the immune response by directly increasing the cytotoxic activity of natural killer cells, macrophages, and neutrophils. Many phytoconstituents prevent cell damage due to their powerful antimicrobial, antioxidant, and anti-inflammatory properties. The present review attempts to understand the molecular mechanisms underlying the immune-enhancing properties of some bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference205 articles.
1. Catanzaro, M., Corsini, E., Rosini, M., Racchi, M., and Lanni, C. (2018). Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea. Molecules, 23. 2. An overview of the immune system;Parkin;Lancet,2001 3. Raducanu, A.E., Tihauan, B.M., Marinas, I.C., Ciuperca, O.T., Tebrencu, C.E., Ionescu, E., and Onisei, T. (2021). The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics. Pharmaceutics, 13. 4. Tieu, S., Charchoglyan, A., Wagter-Lesperance, L., Karimi, K., Bridle, B., Karrow, N., and Mallard, B. (2022). Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness. Nutrients, 14. 5. An introduction to immunology and immunopathology;Marshall;Allergy Asthma Clin. Immunol.,2018
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|