Affiliation:
1. Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea
2. Institute of Industrial Technology, Korea University, Sejong 30019, Republic of Korea
Abstract
Polyphenols from plants such as fruits and vegetables are phytochemicals with physiological and pharmacological activity as potential drugs to modulate oxidative stress and inflammation associated with cardiovascular disease, chronic disease, and cancer. However, due to the limited water solubility and bioavailability of many natural compounds, their pharmacological applications have been limited. Researchers have made progress in the development of nano- and micro-carriers that can address these issues and facilitate effective drug delivery. The currently developed drug delivery systems maximize the fundamental effects in various aspects such as absorption rate, stability, cellular absorption, and bioactivity of polyphenols. This review focuses on the antioxidant and anti-inflammatory effects of polyphenols enhanced by the introduction of drug delivery systems, and ultimately discusses the inhibition of cancer cell proliferation, growth, and angiogenesis.
Funder
Korea Environment Industry & Technology Institute
Korea Ministry of Environment
Korea University and the National Research Foundation of Korea
Korean government
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Reference122 articles.
1. Polyphenol nanoformulations for cancer therapy: Experimental evidence and clinical perspective;Masoomzadeh;Int. J. Nanomed.,2017
2. New insights on oxidative stress in cancer;Visconti;Curr. Opin. Drug Discov. Dev.,2009
3. Oxidative stress, inflammation, and cancer: How are they linked?;Reuter;Free Radic. Biol. Med.,2010
4. Inflammation, ROS, and Mutagenesis;Ruffell;Cancer Cell,2017
5. NF-kappaB, inflammation, immunity and cancer: Coming of age;Taniguchi;Nat. Rev. Immunol.,2018
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献