1. NIHR Southampton Biomedical Research Centre, Respiratory and Critical Care, University Hospital Southampton, Southampton SO16 6YD, UK
2. Academic School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK
3. Department of Critical Care and Anaesthesia, University Hospital Southampton, Southampton SO16 6YD, UK
4. NIHR Southampton Biomedical Research Centre, Nutrition and Metabolism, University Hospital Southampton, Southampton SO16 6YD, UK
5. Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK