A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis
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Published:2023-09-19
Issue:9
Volume:12
Page:1781
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ISSN:2076-3921
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Container-title:Antioxidants
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language:en
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Short-container-title:Antioxidants
Author:
Zou Yuanfeng1ORCID, Yan Hong1, Li Cenyu1, Wen Fang1, Jize Xiaoping1, Zhang Chaowen1, Liu Siqi1, Zhao Yuzhe1, Fu Yuping1ORCID, Li Lixia1, Liu Fan2, Chen Ji2, Li Rui2, Chen Xingfu2, Tian Mengliang2
Affiliation:
1. Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China 2. College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China
Abstract
Aging is a biological process that leads to the progressive deterioration and loss of physiological functions in the human body and results in an increase in morbidity and mortality, and aging-related disease is a major global problem that poses a serious threat to public health. Polysaccharides have been shown to delay aging by reducing oxidative damage, suppressing inflammatory responses, and modulating intestinal microbiota. Our previous studies have shown that polysaccharide CPP-1 extracted from the root of Codonopsis pilosula possesses noticeable anti-oxidant activity in vitro. Thus, in our study, we tested the anti-aging effect of CPP-1 in naturally aging mice (in vivo). Eighteen C57/BL mice (48-week-old, male) were divided into a control group, high-dose CPP-1 group (20 mg/mL), and low-dose CPP-1 group (10 mg/mL). We discovered that CPP-1 can exert a reparative effect on aging stress in the intestine and liver, including alleviating inflammation and oxidative damage. We revealed that CPP-1 supplementation improved the intestinal microbiota composition and repaired the intestinal barrier in the gut. Furthermore, CPP-1 was proved to modulate lipid metabolism and repair hepatocyte injury in the liver by influencing the enterohepatic axis associated with the intestinal microbiota. Therefore, we concluded that CPP-1 prevents and alleviates oxidative stress and inflammatory responses in the intestine and liver of aging mice by modulating the intestinal microbiota-related gut–liver axis to delay aging.
Funder
Genuine Traditional Chinese Medicine Group of Sichuan Innovation Team of National Modern Agricultural Industry Technology System Featured Medicinal Plants Sharing and Service Platform of Sichuan Province
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
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