Author:
Torres Sandra,Abdullah Zeinab,Brol Maximilian J,Hellerbrand Claus,Fernandez Mercedes,Fiorotto Romina,Klein Sabine,Königshofer Philipp,Liedtke Christian,Lotersztajn Sophie,Nevzorova Yulia A.,Schierwagen Robert,Reiberger Thomas,Uschner Frank Erhard,Tacke Frank,Weiskirchen Ralf,Trebicka Jonel
Abstract
Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.
Funder
Deutsche Forschungsgemeinschaft
H2020 European Research Council
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
11 articles.
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