A Novel Photopharmacological Tool: Dual-Step Luminescence for Biological Tissue Penetration of Light and the Selective Activation of Photodrugs

Author:

Menéndez-Velázquez Amador1,García-Delgado Ana Belén1

Affiliation:

1. Photoactive Materials Research Unit, IDONIAL Technology Center, 33417 Avilés, Asturias, Spain

Abstract

Conventional pharmacology lacks spatial and temporal selectivity in terms of drug action. This leads to unwanted side effects, such as damage to healthy cells, as well as other less obvious effects, such as environmental toxicity and the acquisition of resistance to drugs, especially antibiotics, by pathogenic microorganisms. Photopharmacology, based on the selective activation of drugs by light, can contribute to alleviating this serious problem. However, many of these photodrugs are activated by light in the UV–visible spectral range, which does not propagate through biological tissues. In this article, to overcome this problem, we propose a dual-spectral conversion technique, which simultaneously makes use of up-conversion (using rare earth elements) and down-shifting (using organic materials) techniques in order to modify the spectrum of light. Near-infrared light (980 nm), which penetrates tissue fairly well, can provide a “remote control” for drug activation. Once near-IR light is inside the body, it is up-converted to the UV–visible spectral range. Subsequently, this radiation is down-shifted in order to accurately adjust to the excitation wavelengths of light which can selectively activate hypothetical and specific photodrugs. In summary, this article presents, for the first time, a “dual tunable light source” which can penetrate into the human body and deliver light of specific wavelengths; thus, it can overcome one of the main limitations of photopharmacology. It opens up promising possibilities for the moving of photodrugs from the laboratory to the clinic.

Funder

FICYT

European Union

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference58 articles.

1. Photopharmacology and Photochemical Biology;Deiters;ChemPhotoChem,2021

2. A Roadmap to Success in Photopharmacology;Broichhagen;Acc. Chem. Res.,2015

3. The Art of Building Small: From Molecular Switches to Motors (Nobel Lecture);Feringa;Angew. Chem. Int. Ed.,2017

4. Boarder, M., Dixon, J., Newby, D., Navti, P., and Zetterström, T. (2016). Pharmacology for Pharmacy and the Health Sciences: A Patient-Centred Approach, Oxford University Press.

5. Yeager, J.J., McCuistion, L.E., DiMaggio, K.V., and Winton, M.B. (2017). Study Guide for Pharmacology: A Patient-Centered Nursing Process Approach, Elsevier. [9th ed.].

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