Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain-Reference-Cited by-同舟云学术

Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

Published:2023-05-25 Issue:11 Volume:24 Page:9223
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Antunes Flavia Tasmin Techera¹²^ORCID,Campos Maria Martha³^ORCID,Carvalho Vanice de Paula Ricardo⁴,da Silva Junior Claudio Antonio⁴,Magno Luiz Alexandre Viana⁵,de Souza Alessandra Hubner⁵,Gomez Marcus Vinicius⁴^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 1N4, Canada

2. Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 1N4, Canada

3. Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil

4. Faculdade Santa Casa BH, Belo Horizonte 30110-005, MG, Brazil

5. Programa de Pós-Graduação em Ciências da Saúde, Faculdade Ciências Médicas de Minas Gerais (FCMMG), Belo Horizonte 30110-005, MG, Brazil

Abstract

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/11/9223/pdf

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