Cassia alata and Its Phytochemicals: A Promising Natural Strategy in Wound Recovery

Author:

Keng Jing-Wen1ORCID,Lee Sue-Kei1ORCID,Sang Sze-Huey1,Liew Kai-Bin2,Teo Swee-Sen3ORCID,Mossadeq Wan Mastura Shaik Mohamed4ORCID,Chow Sek-Chuen5,Akowuah Gabriel Akyirem6,Lee Siew-Keah7ORCID,Mai Chun-Wai1ORCID,Chew Yik-Ling1ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia

2. Faculty of Pharmacy, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya 63000, Malaysia

3. Faculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia

4. Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Malaysia

5. School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 46150, Malaysia

6. School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 46150, Malaysia

7. M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Kajang 43000, Malaysia

Abstract

Cassia alata, a traditional herb with a global presence, is renowned for its anti-inflammatory, antibacterial, and antifungal properties, making it a go-to remedy for skin ailments. While it has demonstrated wound healing capabilities in both in vitro and in vivo studies, the precise mechanisms remain elusive. This review aims to highlight its key phytochemicals, their effects, and the mechanism of action. The compounds that have been reviewed and discussed include kaempferol, apigenin, quercetin, rhein, and rutin. These polyphenols play important roles in normal and impaired wound healing processes, encompassing hemostasis, inflammation, proliferation, and tissue remodeling.

Funder

Ministry of Higher Education Malaysia

UCSI University

Publisher

MDPI AG

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