Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

Author:

Iweala Emeka Joshua1ORCID,Adurosakin Oluwapelumi Eniola2,Innocent Ugochukwu3,Omonhinmin Conrad A.1ORCID,Dania Omoremime Elizabeth1ORCID,Ugbogu Eziuche Amadike3ORCID

Affiliation:

1. Department of Biochemistry, Covenant University, Ota PMB 1023, Ogun State, Nigeria

2. Department of Microbiology, Ladoke Akintola University of Technology, Ogbomoso PMB 4000, Oyo State, Nigeria

3. Department of Biochemistry, Abia State University, Uturu PMB 2000, Abia State, Nigeria

Abstract

Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-related low autophagy, which are associated with various chronic diseases such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases, promote aging. Interestingly, many medicinal plants and their biologically active compounds have the ability to extend lifespan as they can inhibit oxidative stress and promote autophagy. This review evaluates and provides up-to-date information on the anti-aging potential of bioactive compounds in edible medicinal plants. In this study, seventeen (17) biologically active compounds from edible medicinal plants with anti-aging effects were reviewed. In vivo and in vitro studies showed that these biologically active compounds exhibit anti-aging effects via various mechanisms such as the activation of autophagy, increases in antioxidant enzymes, reductions in reactive oxygen species, the inhibition of inflammatory markers, and the downregulation of senescence genes. This study suggests that edible medicinal plants containing these bioactive compounds may promote health and extend lifespan. However, the exact mechanisms, effective doses, clinical trials, and chronic and genotoxic effects of bioactive compounds as anti-aging agents should be further investigated.

Funder

Transhuman Coin Scientific Advisory Board

Covenant University Centre for Research Innovation and Discovery

Publisher

MDPI AG

Reference207 articles.

1. Okoro, N.O., Odiba, A.S., Osadebe, P.O., Omeje, E.O., Liao, G., Fang, W., Jin, C., and Wang, B. (2021). Bioactive phytochemicals with anti-aging and lifespan extending potentials in Caenorhabditis elegans. Molecules, 26.

2. Song, L., and Zhang, S. (2023). Anti-aging activity and modes of action of compounds from natural food sources. Biomolecules, 13.

3. Zhang, L., Yousefzadeh, M.J., Suh, Y., Niedernhofer, L.J., and Robbins, P.D. (2019). Signal Transduction, Ageing and Disease, Subcellular Biochemistry, Springer.

4. Pandey, K.B., and Suttajit, M. (2023). Chapter 18—Novel plant bioactives, their antiaging potencies: Reality and promises. Plant Bioactives as Natural Panacea against Age-Induced Diseases, Elsevier.

5. (2024, January 16). World Population Prospects. Available online: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/wpp2022_summary_of_results.pdf.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3