Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants Dicranopteris linearis and Psychotria adenophylla-Reference-Cited by-同舟云学术

Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal Plants Dicranopteris linearis and Psychotria adenophylla

Published:2023-09-05 Issue:9 Volume:16 Page:1253
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Duong Thuc-Huy¹^ORCID,Vu Y Thien²,Long Nguyen Phuoc³^ORCID,Phan Nguyen-Hong-Nhi¹⁴,Pham Nguyen-Kim-Tuyen⁴,Sichaem Jirapast⁵,Kieu Nguyen-Khanh-Duy¹,Duong Chi-Bao¹⁴,Nguyen Thanh-Trung⁶⁷,Dang Van-Son⁸⁹,Nguyen Huy Truong²

Affiliation:

1. Department of Chemistry, University of Education, 280 An Duong Vuong Street, District 5, Ho Chi Minh City 700000, Vietnam

2. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam

3. Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 47392, Republic of Korea

4. Faculty of Environment, Sai Gon University, 273 An Duong Vuong, Ward 3, District 5, Ho Chi Minh City 700000, Vietnam

5. Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand

6. Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam

7. Center for Pharmaceutical Biotechnology, School of Medicine and Pharmacy, Duy Tan University, Danang 550000, Vietnam

8. Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam

9. Institute of Tropical Biology, Vietnam Academy of Science and Technology, 85 Tran Quoc Toan Street, District 3, Ho Chi Minh City 700000, Vietnam

Abstract

Little is known about the chemical and biological profiles of Dicranopteris linearis and Psychotria adenophylla. No previous studies have investigated alpha-glucosidase inhibition using extracts from D. linearis and P. adenophylla. In this paper, bioactive-guided isolation procedures were applied to the plants D. linearis and P. adenophylla based on alpha-glucosidase inhibition. From the most active fractions, 20 compounds (DL1–DL13 and PA1–PA7) were isolated. The chemical structures were elucidated using spectroscopic data and compared with those available in the literature. These compounds were evaluated for alpha-glucosidase inhibition, while a molecular docking study was performed to elucidate the mechanisms involved. Consequently, D. linearis and P. adenophylla might serve as a good potential for developing new antidiabetic preparations.

Funder

Ho Chi Minh City University of Education Foundation for Science and Technology

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://www.mdpi.com/1424-8247/16/9/1253/pdf

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