Affiliation:
1. Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore 637616, Singapore
Abstract
Diverse ecologically important metabolites, such as allelochemicals, infochemicals and volatile organic chemicals, are involved in marine organismal interactions. Chemically mediated interactions between intra- and interspecific organisms can have a significant impact on community organization, population structure and ecosystem functioning. Advances in analytical techniques, microscopy and genomics are providing insights on the chemistry and functional roles of the metabolites involved in such interactions. This review highlights the targeted translational value of several marine chemical ecology-driven research studies and their impact on the sustainable discovery of novel therapeutic agents. These chemical ecology-based approaches include activated defense, allelochemicals arising from organismal interactions, spatio-temporal variations of allelochemicals and phylogeny-based approaches. In addition, innovative analytical techniques used in the mapping of surface metabolites as well as in metabolite translocation within marine holobionts are summarized. Chemical information related to the maintenance of the marine symbioses and biosyntheses of specialized compounds can be harnessed for biomedical applications, particularly in microbial fermentation and compound production. Furthermore, the impact of climate change on the chemical ecology of marine organisms—especially on the production, functionality and perception of allelochemicals—and its implications on drug discovery efforts will be presented.
Subject
Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science
Reference218 articles.
1. Marine chemical ecology: Chemical signals and cues structure marine populations, communities, and ecosystems;Hay;Ann. Rev. Mar. Sci.,2009
2. Marine chemical ecology in benthic environments;Puglisi;Nat. Prod. Rep.,2019
3. Chemical ecology of the marine plankton;Brown;Nat. Prod. Rep.,2019
4. Chen, Z.H., Guo, Y.W., and Li, X.W. (2022). Recent advances on marine mollusk-derived natural products: Chemistry, chemical ecology and therapeutical potential. Nat. Prod. Rep.
5. Molecules as biotic messengers;Meinwald;ACS Omega,2018
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