Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats

Author:

Wooden Jessica I.1ORCID,Peacoe Lauren E.1ORCID,Anasooya Shaji Chinchusha1,Melbourne Jennifer K.1,Chandler Cassie M.2,Bardo Michael T.2,Nixon Kimberly1ORCID

Affiliation:

1. Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA

2. Department of Psychology, University of Kentucky, Lexington, KY 40506, USA

Abstract

During adolescence, the brain is highly susceptible to alcohol-induced damage and subsequent neuroimmune responses, effects which may enhance development of an alcohol use disorder (AUD). Neuroimmune reactions are implicated in adolescent alcohol exposure escalating adulthood drinking. Therefore, we investigated whether intermittent alcohol exposure in male, adolescent rats (AIE) escalated adult drinking via two-bottle choice (2BC). We also examined the influence of housing environment across three groups: standard (group-housed with enrichment during 2BC), impoverished (group-housed without enrichment during 2BC), or isolation (single-housed without bedding or enrichment throughout). In the standard group immediately after AIE/saline and after 2BC, we also examined the expression of microglial marker, Iba1, reactive astrocyte marker, vimentin, and neuronal cell death dye, FluoroJade B (FJB). We did not observe an escalation of adulthood drinking following AIE, regardless of housing condition. Further, only a modest neuroimmune response occurred after AIE in the standard group: no significant microglial reactivity or neuronal cell death was apparent using this model, although some astrocyte reactivity was detected in adolescence following AIE that resolved by adulthood. These data suggest that the lack of neuroimmune response in adolescence in this model may underlie the lack of escalation of alcohol drinking, which could not be modified through isolation stress.

Funder

National Institute of Alcohol Abuse and Alcoholism

The University of Texas at Austin College of Pharmacy

Publisher

MDPI AG

Subject

General Medicine

Reference114 articles.

1. World Health Organization (2008). Highlights: Child and Adolescent Health and Development: Progress Report 2006–2007.

2. SAMHSA (2023, October 28). Key Substance Use and Mental Health Indicators in the United States: Results from the 2021 National Survey on Drug Use and Health, Available online: https://www.samhsa.gov/data/report/2021-nsduh-annual-national-report.

3. Miech, R.A., Johnston, L.D., Patrick, M.E., O’Malley, P.M., Bachman, J.G., and Schulenberg, J.E. (2023). Monitoring the Future National Survey Results on Drug Use, 1975–2022: Secondary School Students, Institute for Social Research, University of Michigan.

4. NIAAA (2004). NIAAA Council approves definition of binge drinking. NIAAA Newsl., 3, 3.

5. Adolescent Binge Drinking;Chung;Alcohol. Res. Curr. Rev.,2018

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