Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp.-Reference-Cited by-同舟云学术

Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp.

Published:2024-02-03 Issue:2 Volume:22 Page:78
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Huang Zequan¹²,Liu Dong¹,Chen Shang¹^ORCID,Ren Jinwei³,Gao Chenghai²^ORCID,Li Zhiyong⁴^ORCID,Fan Aili¹^ORCID,Lin Wenhan¹⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

2. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China

3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

4. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

5. Ningbo Institute of Marine Medicine, Peking University, Ningbo 315832, China

Abstract

Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6–10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent.

Funder

the National Key Research and Development Project

National Natural Science Foundation of China

the Ningbo Key Science and Technology Development Program

Open Funding Project of State Key Laboratory of Microbial Metabolism

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

https://www.mdpi.com/1660-3397/22/2/78/pdf

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