The Hallmarks of Cervical Cancer: Molecular Mechanisms Induced by Human Papillomavirus-Reference-Cited by-同舟云学术

The Hallmarks of Cervical Cancer: Molecular Mechanisms Induced by Human Papillomavirus

Published:2024-01-27 Issue:2 Volume:13 Page:77
ISSN:2079-7737
Container-title:Biology
language:en
Short-container-title:Biology

Author:

Rosendo-Chalma Pedro¹²^ORCID,Antonio-Véjar Verónica³^ORCID,Ortiz Tejedor Jonnathan Gerardo²⁴^ORCID,Ortiz Segarra Jose⁵^ORCID,Vega Crespo Bernardo⁵^ORCID,Bigoni-Ordóñez Gabriele Davide⁶^ORCID

Affiliation:

1. Laboratorio de Virus y Cáncer, Unidad de Investigación Biomédica en Cáncer of Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (IIB-UNAM), Mexico City 14080, Mexico

2. Unidad Académica de Posgrado, Universidad Católica de Cuenca, Cuenca 010101, Ecuador

3. Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, Guerrero, Mexico

4. Carrera de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca 010101, Ecuador

5. Carrera de Medicina, Facultad de Ciencias Médicas, Universidad de Cuenca, Cuenca 010107, Ecuador

6. Carrera de Laboratorio Clínico, Facultad de Ciencias Médicas, Universidad de Cuenca, Cuenca 010107, Ecuador

Abstract

Human papillomaviruses (HPVs) and, specifically, high-risk HPVs (HR-HPVs) are identified as necessary factors in the development of cancer of the lower genital tract, with CaCU standing out as the most prevalent tumor. This review summarizes ten mechanisms activated by HR-HPVs during cervical carcinogenesis, which are broadly associated with at least seven of the fourteen distinctive physiological capacities of cancer in the newly established model by Hanahan in 2022. These mechanisms involve infection by human papillomavirus, cellular tropism, genetic predisposition to uterine cervical cancer (CaCU), viral load, viral physical state, regulation of epigenetic mechanisms, loss of function of the E2 protein, deregulated expression of E6/E7 oncogenes, regulation of host cell protein function, and acquisition of the mesenchymal phenotype.

Funder

Universidad de Cuenca

Publisher

MDPI AG

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology

Link

https://www.mdpi.com/2079-7737/13/2/77/pdf

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