AIF1: Function and Connection with Inflammatory Diseases-Reference-Cited by-同舟云学术

AIF1: Function and Connection with Inflammatory Diseases

Published:2023-05-09 Issue:5 Volume:12 Page:694
ISSN:2079-7737
Container-title:Biology
language:en
Short-container-title:Biology

Author:

De Leon-Oliva Diego¹²,Garcia-Montero Cielo¹²^ORCID,Fraile-Martinez Oscar¹²^ORCID,Boaru Diego Liviu¹²,García-Puente Luis¹²,Rios-Parra Antonio¹²³,Garrido-Gil Maria J.¹,Casanova-Martín Carlos¹²,García-Honduvilla Natalio¹²^ORCID,Bujan Julia¹²^ORCID,Guijarro Luis G.¹²⁴,Alvarez-Mon Melchor¹²⁵^ORCID,Ortega Miguel A.¹²³^ORCID

Affiliation:

1. Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain

2. Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain

3. Cancer Registry and Pathology Department, Principe de Asturias University Hospital, 28806 Alcala de Henares, Spain

4. Unit of Biochemistry and Molecular Biology, Department of System Biology (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain

5. Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine (CIBEREHD), University Hospital Príncipe de Asturias, 28806 Alcala de Henares, Spain

Abstract

Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.

Funder

Instituto de Salud Carlos III

European Development Regional Fund “A way to achieve Europe”

Comunidad de Madrid

Publisher

MDPI AG

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology

Link

https://www.mdpi.com/2079-7737/12/5/694/pdf

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