Affiliation:
1. Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract
Hypertension can cause structural and functional abnormalities in the cardiovascular system, which can be attributed to both hemodynamic and nonhemodynamic factors. These alterations are linked with metabolic changes and are induced by pathological stressors. Sirtuins are enzymes that act as stress sensors and regulate metabolic adaptation by deacetylating proteins. Among them, mitochondrial SIRT3 performs a crucial role in maintaining metabolic homeostasis. Evidence from experimental and clinical studies has shown that hypertension-induced decreases in SIRT3 activity can lead to cellular metabolism reprogramming and, subsequently, increased susceptibility to endothelial dysfunction, myocardial hypertrophy, myocardial fibrosis, and heart failure. This review presents recent research advances in SIRT3-mediated metabolic adaptation in hypertensive cardiovascular remodeling.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shanghai
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology
Reference108 articles.
1. The global epidemiology of hypertension;Mills;Nat. Rev. Nephrol.,2020
2. Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment;Azevedo;Arq. Bras. Cardiol.,2016
3. Left ventricular remodeling and dysfunction in primary aldosteronism;Tsai;J. Hum. Hypertens.,2021
4. Myocardial proteases and cardiac remodeling;Riaz;J. Cell Physiol.,2017
5. Lysine acetylation targets protein complexes and co-regulates major cellular functions;Choudhary;Science,2009