Author:
Greenan-Barrett James,Doolan Georgia,Shah Devina,Virdee Simrun,Robinson George A.,Choida Varvara,Gak Nataliya,de Gruijter Nina,Rosser Elizabeth,Al-Obaidi Muthana,Leandro Maria,Zandi Michael S.,Pepper Ruth J.,Salama Alan,Jury Elizabeth C.,Ciurtin Coziana
Abstract
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.
Funder
Versus Arthritis
UCLH Biomedical Research Centre
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
14 articles.
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