Botulinum Neurotoxin Injections in Children with Self-Injurious Behaviors

Author:

Hull Mariam12ORCID,Parnes Mered12ORCID,Jankovic Joseph2

Affiliation:

1. Pediatric Movement Disorders Clinic, Section of Pediatric Neurology and Developmental Neuroscience, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USA

2. Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA

Abstract

Self-injurious behaviors are repetitive, persistent actions directed toward one’s body that threaten or cause physical harm. These behaviors are seen within a broad spectrum of neurodevelopmental and neuropsychiatric conditions, often associated with intellectual disability. Injuries can be severe and distressing to patients and caregivers. Furthermore, injuries can be life-threatening. Often, these behaviors are challenging to treat and require a tiered, multimodal approach which may include mechanical/physical restraints, behavioral therapy, pharmacotherapy, or in some cases, surgical management, such as tooth extraction or deep brain stimulation. Here, we describe a series of 17 children who presented to our institution with self-injurious behaviors in whom botulinum neurotoxin injections were found helpful in preventing or lessening self-injury.

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Toxicology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Tics emergencies and malignant tourette syndrome: Assessment and management;Neuroscience & Biobehavioral Reviews;2024-04

2. Emergencies in tic and choreic disorders;Movement Disorders Emergencies;2023

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