A 2D Magneto-Acousto-Electrical Tomography Method to Detect Conductivity Variation Using Multifocus Image Method

Abstract

As magneto-acoustic-electrical tomography (MAET) combines the merits of high contrast and high imaging resolution, and is extremely useful for electrical conductivity measurement, so it is expected to be a promising medical imaging modalities for diagnosis of early-stage cancer. Based on the Verasonics system and the MC600 displacement platform, we designed and implemented a MAET system with a chirp pulse stimulation (MAET-CPS) method and a focal probe was utilized for stepscan focus excitation to enhance the imaging resolution. The relevant experiments were conducted to explore the influence of excitation positions of the single-focus point, and the effect of the excitation position on the amplitudes of the conductivity variation was clearly demonstrated. In order to take advantage of the merits of multifocus imaging, we firstly proposed a single focus MAET system with a chirp pulse stimulation (sfMAET-CPS) method and a multifocus MAET system with a chirp pulse stimulation (mfMAET-CPS) method for high-resolution conductivity imaging, and a homogenous gelatin phantom with a cuboid-shaped hole was used to investigate the accuracy of mfMAET-CPS. Comparative experiments were carried out on the same uniform phantom by the sfMAET-CPS and the mfMAET-CPS, respectively. The results showed that: (1) the electrical conductivity distributions of the homogenous phantom with a cuboid-shaped hole were detected by the sfMAET-CPS but were easily affected by the focal point, which demonstrated that the sfMAET-CPS had a low imaging resolution. (2) Compared with the sfMAET-CPS, the imaging effect of the mfMAET-CPS was much better than that of the sfMAET-CPS. (3) A linear interpolation algorithm was used to process the 2D conductivity distribution; it increased the smoothness of the conductivity distribution and improved the imaging effect. The stepscan focus excitation and the linearly frequency-modulated theory provide an alternative scheme for the clinical application of MAET.