Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations

Author:

Gómez-Zorita Saioa123ORCID,Milton-Laskibar Iñaki123ORCID,Eseberri Itziar123,Beaumont Pauline45,Courtois Arnaud456ORCID,Krisa Stéphanie45ORCID,Portillo María P.123ORCID

Affiliation:

1. Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Centre, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain

2. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, 28222 Madrid, Spain

3. BIOARABA Health Research Institute, 01006 Vitoria-Gasteiz, Spain

4. Univ. Bordeaux, Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, F-33140 Villenave d’Ornon, France

5. Bordeaux Sciences Agro, Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, F-33170 Gradignan, France

6. Centre Antipoison de Nouvelle Aquitaine, CHU de Bordeaux, 33076 Bordeaux, France

Abstract

Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, ε-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that ε-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that ε-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. ε-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use ε-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods.

Funder

CIBEROBN

Government of the Basque Country

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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