Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy

Author:

Sarasati Andari1ORCID,Syahruddin Muhammad Hidayat1ORCID,Nuryanti Archadian2,Ana Ika Dewi23ORCID,Barlian Anggraini4,Wijaya Christofora Hanny5,Ratnadewi Diah6,Wungu Triati Dewi Kencana7,Takemori Hiroshi8ORCID

Affiliation:

1. Doctoral Study Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia

2. Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia

3. Research Collaboration Center for Biomedical Scaffolds, National Research and Innovation Agency of the Republic of Indonesia, Yogyakarta 55281, Indonesia

4. School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia

5. Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, IPB University, Bogor 16002, Indonesia

6. Department of Biology, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16002, Indonesia

7. Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung 40132, Indonesia

8. Department of Chemistry and Biomolecular Science, Faculty of Engineering and Graduate School of Engineering, Gifu University, Gifu 501-1193, Japan

Abstract

Plant-derived exosome-like nanoparticles (PDENs) comprise various bioactive biomolecules. As an alternative cell-free therapeutic approach, they have the potential to deliver nano-bioactive compounds to the human body, and thus lead to various anti-inflammatory, antioxidant, and anti-tumor benefits. Moreover, it is known that Indonesia is one of the herbal centers of the world, with an abundance of unexplored sources of PDENs. This encouraged further research in biomedical science to develop natural richness in plants as a source for human welfare. This study aims to verify the potential of PDENs for biomedical purposes, especially for regenerative therapy applications, by collecting and analyzing data from the latest relevant research and developments.

Funder

Indonesia Collaborative Research (RKI) Funding Scheme under World Class University Acceleration Program from the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

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