Affiliation:
1. Faculty of Pharmacy, Research Institute for Medicines (iMed.Ulisboa), Universidade de Lisboa, 1649-003 Lisbon, Portugal
Abstract
Cancer is a societal burden demanding innovative approaches. A major problem with the conventional chemotherapeutic agents is their strong toxicity and other side effects due to their poor selectivity. Uncontrolled proliferation of cancer cells is due to mutations, deletions, or amplifications in genes (oncogenes) encoding for proteins that regulate cell growth and division, such as transcription factors, for example, c-MYC. The direct targeting of the c-MYC protein has been attempted but so far unsuccessfully, as it lacks a definite binding site for the modulators. Meanwhile, another approach has been explored since the discovery that G-quadruplex secondary DNA structures formed in the guanine-rich sequences of the c-MYC promoter region can downregulate the transcription of this oncogene. Here, we will overview the major achievements made in the last decades towards the discovery of a new class of anticancer drugs targeting G-quadruplexes in the c-MYC promoter of cancer cells.
Funder
Fundação para a Ciência e Tecnologia
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference131 articles.
1. (2022, October 07). World Health Organization Estimated Number of New Cases in 2020. Available online: https://gco.iarc.fr/today/online-analysis-table?v=2020&mode=cancer&mode_population=continents&population=900&populations=900&key=asr&sex=0&cancer=39&type=0&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D=17&group_cancer=1&include_nmsc=0&include_nmsc_other=1.
2. Recent Trends in Cancer Therapy: A Review on the Current State of Gene Delivery;Yahya;Life Sci.,2021
3. The Different Mechanisms of Cancer Drug Resistance: A Brief Review;Mansoori;Adv. Pharm. Bull.,2017
4. (2022, October 07). World Health Organization Cancer. Available online: https://www.who.int/health-topics/cancer#tab=tab_1.
5. Emerging Landscape of Oncogenic Signatures across Human Cancers;Ciriello;Nat. Genet.,2013
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