Affiliation:
1. Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow 107031, Russia
2. Department of Pathological Anatomy, Institute of Medicine, Peoples’ Friendship University of Russia, Moscow 117198, Russia
Abstract
Despite the enormous interest in COVID-19, there is no clear understanding of the mechanisms underlying the neurological symptoms in COVID-19. Microglia have been hypothesized to be a potential mediator of the neurological manifestations associated with COVID-19. In most existing studies to date, morphological changes in internal organs, including the brain, are considered in isolation from clinical data and defined as a consequence of COVID-19. We performed histological immunohistochemical (IHC) studies of brain autopsy materials of 18 patients who had died from COVID-19. We evaluated the relationship of microglial changes with the clinical and demographic characteristics of the patients. The results revealed neuronal alterations and circulatory disturbances. We found an inverse correlation between the integral density Iba-1 (microglia/macrophage-specific marker) IHC staining and the duration of the disease (R = −0.81, p = 0.001), which may indicate a reduced activity of microglia and do not exclude their damage in the long-term course of COVID-19. The integral density of Iba-1 IHC staining was not associated with other clinical and demographic factors. We observed a significantly higher number of microglial cells in close contact with neurons in female patients, which confirms gender differences in the course of the disease, indicating the need to study the disease from the standpoint of personalized medicine.
Funder
Ministry of Science and Higher Education of Russian Federation
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference73 articles.
1. WHO declares COVID-19 a pandemic;Cucinotta;Acta Biomed.,2020
2. (2023, March 24). WHO Coronavirus (COVID-19) Dashboard. Available online: https://covid19.who.int/table.
3. Severe Neurologic Complications of SARS-CoV-2;Sisniega;Curr. Treat. Options. Neurol.,2021
4. Signs and Symptoms of Central Nervous System Involvement and Their Pathogenesis in COVID-19 According to the Clinical Data (Review);Tsygan;Gen. Reanimatol.,2021
5. Post-acute COVID-19 syndrome;Nalbandian;Nat. Med.,2021
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献