Abstract
Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some polyaminopyrimidines and mitochondrial-targeting peptoids, has been linked with mitochondrial localization and targeting. Over the past two decades, increasing evidence has emerged showing pyrvinium to be a strong anti-cancer molecule in various human cancers in vitro and in vivo. This efficacy against cancers has been attributed to diverse mechanisms of action, with the weight of evidence supporting the inhibition of mitochondrial function, the WNT pathway, and cancer stem cell renewal. Despite the overwhelming evidence demonstrating the efficacy of pyrvinium for the treatment of human cancers, pyrvinium has not yet been repurposed for the treatment of cancers. This review provides an in-depth analysis of the history of pyrvinium as a therapeutic, the rationale and data supporting its use as an anticancer agent, and the challenges associated with repurposing pyrvinium as an anti-cancer agent.
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference154 articles.
1. Sil, D., Panja, S., Jogdeo, C.M., Kumar, R., Yu, A., Holbert, C.E., Ding, L., Foley, J.R., Stewart, T.M., and Casero, R.A. (2022). Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents. Molecules, 27.
2. Development of polyamine analogs as cancer therapeutic agents;Thomas;Oncol. Res.,2002
3. Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program;Smith;Pediatr. Blood Cancer,2011
4. Unbiased peptoid cell screen identifies a peptoid targeting newly appeared cell surface vimentin on tumor transformed early lung cancer cells;Shukla;Bioorg. Med. Chem.,2022
5. Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics;Raudszus;Bioorg. Med. Chem.,2019
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