Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction-Reference-Cited by-同舟云学术

Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction

Published:2023-10-17 Issue:10 Volume:11 Page:2815
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Rabkin Simon W.¹²^ORCID,Wong Chenille N.¹^ORCID

Affiliation:

1. Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

2. Division of Cardiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada

Abstract

This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca2+-ATPase, oxidative–nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/10/2815/pdf

Reference99 articles.

1. Epidemiology of heart failure;Roger;Circ. Res.,2013

2. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC;McDonagh;Eur. Heart J.,2021

3. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines;Heidenreich;J. Am. Coll. Cardiol.,2022

4. Evaluating the adverse outcome of subtypes of heart failure with preserved ejection fraction defined by machine learning: A systematic review focused on defining high risk phenogroups;Rabkin;EXCLI. J.,2022

5. Cellular and molecular pathobiology of heart failure with preserved ejection fraction;Mishra;Nat. Rev. Cardiol.,2021