Affiliation:
1. Institute of Science and Technology for Ceramics, National Research Council, 48018 Faenza, Italy
Abstract
Material science is a relevant discipline in support of regenerative medicine. Indeed, tissue regeneration requires the use of scaffolds able to guide and sustain the natural cell metabolism towards tissue regrowth. This need is particularly important in musculoskeletal regeneration, such as in the case of diseased bone or osteocartilaginous regions for which calcium phosphate-based scaffolds are considered as the golden solution. However, various technological barriers related to conventional ceramic processing have thus far hampered the achievement of biomimetic and bioactive scaffolds as effective solutions for still unmet clinical needs in orthopaedics. Driven by such highly impacting socioeconomic needs, new nature-inspired approaches promise to make a technological leap forward in the development of advanced biomaterials. The present review illustrates ion-doped apatites as biomimetic materials whose bioactivity resides in their unstable chemical composition and nanocrystallinity, both of which are, however, destroyed by the classical sintering treatment. In the following, recent nature-inspired methods preventing the use of high-temperature treatments, based on (i) chemically hardening bioceramics, (ii) biomineralisation process, and (iii) biomorphic transformations, are illustrated. These methods can generate products with advanced biofunctional properties, particularly biomorphic transformations represent an emerging approach that could pave the way to a technological leap forward in medicine and also in various other application fields.
Funder
Seventh Framework Programme
Sixth Framework Programme
Regione Emilia-Romagna
Reference177 articles.
1. Biomimetic Scaffolds for Bone Tissue Engineering;Noh;Biomimetic Medical Materials,2018
2. Baino, F. (2017). Fabrication Methodologies of Biomimetic and Bioactive Scaffolds for Tissue Engineering Applications. Scaffolds in Tissue Engineering-Materials, Technologies and Clinical Applications, InTech.
3. Sprio, S., Sandri, M., Iafisco, M., Panseri, S., Cunha, C., Ruffini, A., Zini, N., Toni, R., and Tampieri, A. (2013). Biomimetic materials in regenerative medicine. Biomimetic Biomaterials, Elsevier.
4. Functionalized Biomimetic Calcium Phosphates for Bone Tissue Repair;Bigi;J. Appl. Biomater. Funct. Mater.,2017
5. Biomimetics of Bone Implants: The Regenerative Road;Brett;BioRes. Open Access,2017
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献