Affiliation:
1. NEURO-DOL, INSERM (Institut National de la Santé et de la Recherche Médicale), Université Clermont Auvergne, 63000 Clermont-Ferrand, France
Abstract
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in numerous physiological functions and plays a key role in pain modulation including neuropathic pain. Diabetic neuropathy is a common complication of diabetes mellitus often accompanied by chronic neuropathic pain. Animal models of diabetes offer relevant tools for studying the pathophysiological mechanisms and pharmacological sensitivity of diabetic neuropathic pain and for identifying new therapeutic targets. In this review, we report data from preclinical work published over the last 15 years on the analgesic activity of drugs acting on the serotonergic system, such as serotonin and noradrenaline reuptake inhibitor (SNRI) antidepressants, and on the involvement of certain serotonin receptors-in particular 5-HT1A, 5-HT2A/2c and 5-HT6 receptors-in rodent models of painful diabetic neuropathy.
Funder
Agence Nationale de la Recherche
“Investissements d’Avenir”
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference65 articles.
1. A New Definition of Neuropathic Pain;Jensen;Pain,2011
2. Ding, X., Fang, C., Li, X., Cao, Y.-J., Zhang, Q.-L., Huang, Y., Pan, J., and Zhang, X. (2019). Type 1 Diabetes-Associated Cognitive Impairment and Diabetic Peripheral Neuropathy in Chinese Adults: Results from a Prospective Cross-Sectional Study. BMC Endocr. Disord., 19.
3. Type 2 Diabetes Mellitus and Cognitive Impairment;Damanik;Acta Medica Indones.,2021
4. Neuropathy and Presence of Emotional Distress and Depression in Longstanding Diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes;Bai;J. Diabetes Its Complicat.,2017
5. Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments;Tesfaye;Diabetes Care,2010