Vitamin D and Mitosis Evaluation in Endometriosis: A Step toward Discovering the Connection?-Reference-Cited by-同舟云学术

Vitamin D and Mitosis Evaluation in Endometriosis: A Step toward Discovering the Connection?

Published:2023-07-26 Issue:8 Volume:11 Page:2102
ISSN:2227-9059
Container-title:Biomedicines
language:en
Short-container-title:Biomedicines

Author:

Matasariu Daniela Roxana¹²^ORCID,Mandici Cristina Elena¹,Ursache Alexandra¹²^ORCID,Bausic Alexandra Irma Gabriela³⁴,Bujor Iuliana Elena¹,Cristofor Alexandra Elena¹,Boiculese Lucian Vasile⁵,Grigore Mihaela¹²,Bratila Elvira³⁴^ORCID,Lozneanu Ludmila⁶^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania

2. Department of Obstetrics and Gynecology, “Cuza Vodă” Hospital, 700038 Iasi, Romania

3. Department of Obstetrics and Gynecology, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania

4. Department of Obstetrics and Gynecology, “Prof. Dr. Panait Sîrbu” Obstetrics and Gynecology Hospital, 060251 Bucharest, Romania

5. Biostatistics, Department of Preventive Medicine and Interdisciplinarity, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania

6. Department of Morpho-Functional Sciences I—Histology, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania

Abstract

(1) Background: The effects of serum vitamin D levels, the vitamin D receptor (VDR), and phosphohistone H3 (PHH3) in endometriosis were investigated in two cohorts of women with this pathology: those receiving hormonal treatment and those without treatment. (2) Methods: In 60 cases of women with endometriosis (26 with progestin treatment and 34 without), paraffin-embedded endometriosis tissue samples retrieved after surgery were immunohistochemically (IHC) analyzed to determine the expression statuses of VDR and PHH3. In addition, serum levels of 25(OH) vitamin D were assessed for each patient. (3) Results: The serum 25(OH) vitamin D evaluations revealed higher levels of 25(OH) vitamin D in women with treatment compared with those without. The positive IHC indexes of VDR and PHH3 in these two groups were compared. Vitamin D receptor levels were positively correlated with PHH3 levels, both being increased in patients without treatment. (4) Conclusions: Serum 25(OH) vitamin D levels and IHC analysis of VDR and PHH3 can be used as additional tools for risk stratification and prognostic assessment in patients with endometriosis.

Funder

the University of Medicine and Pharmacy “GR. T. POPA”, IAŞI, Romania

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Link

https://www.mdpi.com/2227-9059/11/8/2102/pdf

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