‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Author:

Parry Peter I.12ORCID,Lefringhausen Astrid3,Turni Conny4ORCID,Neil Christopher J.5ORCID,Cosford Robyn3ORCID,Hudson Nicholas J.6ORCID,Gillespie Julian3

Affiliation:

1. Children’s Health Research Clinical Unit, Faculty of Medicine, The University of Queensland, South Brisbane, QLD 4101, Australia

2. Department of Psychiatry, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia

3. Children’s Health Defence (Australia Chapter), Huskisson, NSW 2540, Australia

4. Microbiology Research, QAAFI (Queensland Alliance for Agriculture and Food Innovation), The University of Queensland, St. Lucia, QLD 4072, Australia

5. Department of Medicine, University of Melbourne, Melbourne, VIC 3010, Australia

6. School of Agriculture and Food Science, The University of Queensland, Brisbane, QLD 4072, Australia

Abstract

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely.

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Reference253 articles.

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5. Therapeutic Goods Administration (TGA) FOI Reply 2389-6, p.45 (2023, April 07). Nonclinical Evaluation Report: BNT162b2 [mRNA] COVID-19 Vaccine (COMIRNATYTM). Submission No: PM-2020-05461-1-2. Sponsor: Pfizer Australia Pty Ltd. Australian Government Department of Health and Aged Care: 2021; FOI reply 2389-6, Available online: https://www.tga.gov.au/sites/default/files/foi-2389-06.pdf.

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