Immunological and Haematological Relevance of Helminths and Mycobacterium tuberculosis Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso

Author:

Djibougou Diakourga Arthur123,Mensah Gloria Ivy4ORCID,Kaboré Achille5,Toé Inoussa13,Sawadogo Leon Tinnoga16,Lompo Palpouguini Felix7,Kone Amariane M. M.2,Hien Hervé23,Meda Clement Ziemlé12ORCID,Combary Adjima6,Bonfoh Bassirou8ORCID,Addo Kennedy Kwasi4ORCID,Belem Adrien Marie-Gaston1,Dabiré Roch Konbobr23ORCID,Hoffmann Jonathan9,Perreau Matthieu10,Diagbouga Potiandi Serge37

Affiliation:

1. Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso

2. Infectious Diseases Program, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso 1091, Burkina Faso

3. Institut de Recherche en Sciences de la Santé, CNRST, Bobo-Dioulasso 545, Burkina Faso

4. Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra 00233, Ghana

5. Infectious Disease and Health Systems (IDHS), FHI 360, Washington, DC 20037, USA

6. National Tuberculosis Programme, Ministry of Health and Public Hygiene, Ouagadougou 01 P.O. Box 690, Burkina Faso

7. Etudes Formation et Recherches Développement en Santé (EFORDS), Ouagadougou 10 P.O. Box 13064, Burkina Faso

8. Centre Suisse de Recherches Scientifique de Côte d’Ivoire, Adiopodoumé 01 P.O. Box 1303, Côte d’Ivoire

9. Département Médical et Scientifique, Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France

10. Faculty of Biology and Medicine, Université de Lausanne, 1010 Lausanne, Switzerland

Abstract

The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (n = 82), as control, were participants without helminthic or Mycobacterium tuberculosis complex infection (Mtb−/Helm−), group 2 (n = 73) were TB patients without helminthic infection (Mtb+/Helm−), and group 3 (n = 22) were TB patients with helminthic infection (Mtb+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and Schistosoma mansoni infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the Mtb complex (Mtb+/Helm+) compared to the other groups (p < 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups (p > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the Mtb+/Helm+ and Mtb+/Helm− patients. Exploring these types of immune–haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis–helminthiasis coinfection.

Funder

Afrique One-ASPIRE

Afrique One-REACH

World Bank African Centres of Excellence

Welcome Trust DELTA

Publisher

MDPI AG

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5. Alemu, A., Bitew, Z.W., and Worku, T. (2020). Intestinal Parasites Co-Infection among Tuberculosis Patients in Ethiopia: A Systematic Review and Meta-Analysis. BMC Infect. Dis., 20.

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