Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway

Author:

Wang Mengyao1,Zhang Feng1,Zhou Jie1,Gong Ke1,Chen Shasha1,Zhu Xinran1,Zhang Mengxue1,Duan Yajun2,Liao Chenzhong1ORCID,Han Jihong1ORCID,Yin Zequn2ORCID

Affiliation:

1. College of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China

2. Department of Cardiology, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

Abstract

Licorice is a traditional and versatile herbal medicine and food. Glabridin (Gla) is a kind of isoflavone extracted from the licorice root, which has anti-obesity, anti-atherosclerotic, and antioxidative effects. Alcoholic liver disease (ALD) is a widespread liver disease induced by chronic alcohol consumption. However, studies demonstrating the effect of Gla on ALD are rare. The research explored the positive effect of Gla in C57BL/6J mice fed by the Lieber–DeCarli ethanol mice diet and HepG2 cells treated with ethanol. Gla alleviated ethanol-induced liver injury, including reducing liver vacuolation and lipid accumulation. The serum levels of inflammatory cytokines were decreased in the Gla-treated mice. The reactive oxygen species and apoptosis levels were attenuated and antioxidant enzyme activity levels were restored in ethanol-induced mice by Gla treatment. In vitro, Gla reduced ethanol-induced cytotoxicity, nuclear factor kappa B (NF-κB) nuclear translocation, and enhanced nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation. Anisomycin (an agonist of p38 MAPK) eliminated the positive role of Gla on ethanol-caused oxidative stress and inflammation. On the whole, Gla can alleviate alcoholic liver damage via the p38 MAPK/Nrf2/NF-κB pathway and may be used as a novel health product or drug to potentially alleviate ALD.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Grants

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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