The Plant Defensin Ppdef1 Is a Novel Topical Treatment for Onychomycosis
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Published:2023-11-17
Issue:11
Volume:9
Page:1111
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ISSN:2309-608X
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Container-title:Journal of Fungi
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language:en
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Short-container-title:JoF
Author:
van der Weerden Nicole L.12, Parisi Kathy12, McKenna James A.12, Hayes Brigitte M.12, Harvey Peta J.3ORCID, Quimbar Pedro12, Wevrett Sean R.4, Veneer Prem K.12, McCorkelle Owen12, Vasa Shaily12, Guarino Rosemary12, Poon Simon12, Gaspar Yolanda M.12, Baker Michael J.12, Craik David J.3ORCID, Turner Rob B.4, Brown Marc B.4, Bleackley Mark R.12, Anderson Marilyn A.12
Affiliation:
1. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia 2. Hexima Ltd., La Trobe University, Melbourne, VIC 3086, Australia 3. Institute for Molecular Bioscience, The Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia 4. MedPharm Ltd., Surrey Research Park, Surrey GU2 7AB, UK
Abstract
Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also have psychological and social consequences for the patient. Treatment of onychomycosis is complicated by the location of the infection under the nail plate, meaning that antifungal molecules must either penetrate the nail or be applied systemically. Currently, available treatments are limited by their poor nail penetration for topical products or their potential toxicity for systemic products. Plant defensins with potent antifungal activity have the potential to be safe and effective treatments for fungal infections in humans. The cystine-stabilized structure of plant defensins makes them stable to the extremes of pH and temperature as well as digestion by proteases. Here, we describe a novel plant defensin, Ppdef1, as a peptide for the treatment of fungal nail infections. Ppdef1 has potent, fungicidal activity against a range of human fungal pathogens, including Candida spp., Cryptococcus spp., dermatophytes, and non-dermatophytic moulds. In particular, Ppdef1 has excellent activity against dermatophytes that infect skin and nails, including the major etiological agent of onychomycosis Trichophyton rubrum. Ppdef1 also penetrates human nails rapidly and efficiently, making it an excellent candidate for a novel topical treatment of onychomycosis.
Funder
Hexima Ltd. ARC Centre of Excellence for Innovations in Peptide and Protein Science Australian Research Council Laureate Fellowship
Subject
Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)
Reference50 articles.
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