Neurogenic Bowel Dysfunction in Patients with Spinal Cord Injury and Multiple Sclerosis—An Updated and Simplified Treatment Algorithm

Author:

Magnuson Fredrika1,Christensen Peter2,Krassioukov Andrei3ORCID,Rodriguez Gianna4,Emmanuel Anton5,Kirshblum Steven67,Krogh Klaus1

Affiliation:

1. Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8200 Aarhus, Denmark

2. Department of Surgery, Aarhus University Hospital, 8200 Aarhus, Denmark

3. International Collaboration of Repair Discoveries (ICORD), Department of Medicine, Division of Physical Medicine and Rehabilitation, The University of British Columbia, Vancouver, BC V5Z 1M9, Canada

4. Physical Medicine and Rehabilitation, Spinal Cord Injury Medicine, University of Michigan Health, Ann Arbor, MI 48108, USA

5. GI Physiology Unit, University College London Hospital, London WC1E 6DB, UK

6. Kessler Institute for Rehabilitation, West Orange, NJ 07052, USA

7. Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA

Abstract

Neurogenic bowel dysfunction (NBD) is a common condition in individuals with spinal cord injury (SCI) or multiple sclerosis (MS). It usually entails constipation, difficult evacuation of the rectum, and fecal incontinence (FI); often in combination. It is highly burdensome for affected patients and is correlated with poor quality of life. The current treatment algorithm, or treatment pyramid, does not completely correspond to actual clinical practice, and the known and classical pyramid contains both treatments still in their experimental stage as well as several treatments which are not available at all treatment centers. Thus, an updated treatment algorithm is called upon, and the authors of this paper therefore propose a simplified version of the treatment pyramid, aiming to guide clinicians in treating NBD.

Funder

Coloplast Denmark

Publisher

MDPI AG

Subject

General Medicine

Reference80 articles.

1. A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients;Christensen;Gastroenterology,2006

2. Consortium Spinal Cord Medicine CPG (2021). Clinical Practice Guidelines: Spinal Cord Medicine, American Spinal Injury Association.

3. Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease;Preziosi;Eur. J. Gastroenterol. Hepatol.,2013

4. Transanal Irrigation for Neurogenic Bowel Dysfunction in Multiple Sclerosis: A Retrospective Study;Teng;J. Neurogastroenterol. Motil.,2022

5. Long-term efficacy and safety of transanal irrigation in multiple sclerosis;Passananti;Neurogastroenterol. Motil.,2016

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