Timely Monitoring of SARS-CoV-2 RNA Fragments in Wastewater Shows the Emergence of JN.1 (BA.2.86.1.1, Clade 23I) in Berlin, Germany
Author:
Bartel Alexander1ORCID, Grau José Horacio2, Bitzegeio Julia1ORCID, Werber Dirk1, Linzner Nico3, Schumacher Vera3, Garske Sonja1, Liere Karsten2ORCID, Hackenbeck Thomas2, Rupp Sofia Isabell2, Sagebiel Daniel1, Böckelmann Uta3, Meixner Martin2
Affiliation:
1. Unit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany 2. amedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany 3. Laboratory of Berliner Wasserbetriebe, Berliner Wasserbetriebe, 13629 Berlin, Germany
Abstract
The importance of COVID-19 surveillance from wastewater continues to grow since case-based surveillance in the general population has been scaled back world-wide. In Berlin, Germany, quantitative and genomic wastewater monitoring for SARS-CoV-2 is performed in three wastewater treatment plants (WWTP) covering 84% of the population since December 2021. The SARS-CoV-2 Omicron sublineage JN.1 (B.2.86.1.1), was first identified from wastewater on 22 October 2023 and rapidly became the dominant sublineage. This change was accompanied by a parallel and still ongoing increase in the notification-based 7-day-hospitalization incidence of COVID-19 and COVID-19 ICU utilization, indicating increasing COVID-19 activity in the (hospital-prone) population and a higher strain on the healthcare system. In retrospect, unique mutations of JN.1 could be identified in wastewater as early as September 2023 but were of unknown relevance at the time. The timely detection of new sublineages in wastewater therefore depends on the availability of new sequences from GISAID and updates to Pango lineage definitions and Nextclade. We show that genomic wastewater surveillance provides timely public health evidence on a regional level, complementing the existing indicators.
Subject
Virology,Infectious Diseases
Reference19 articles.
1. Zhakparov, D., Quirin, Y., Xiao, Y., Battaglia, N., Holzer, M., Bühler, M., Kistler, W., Engel, D., Zumthor, J.P., and Caduff, A. (2023). Sequencing of SARS-CoV-2 RNA Fragments in Wastewater Detects the Spread of New Variants during Major Events. Microorganisms, 11. 2. GISAID: Global Initiative on Sharing All Influenza Data—From Vision to Reality;Shu;Eurosurveillance,2017 3. Predicting COVID-19 Incidence Using Wastewater Surveillance Data, Denmark, October 2021–June 2022;McManus;Emerg. Infect. Dis.,2023 4. Early Detection of the Emerging SARS-CoV-2 BA.2.86 Lineage through Integrated Genomic Surveillance of Wastewater and COVID-19 Cases in Sweden, Weeks 31 to 38 2023;Berg;Eurosurveillance,2023 5. Wastewater Sequencing Reveals Early Cryptic SARS-CoV-2 Variant Transmission;Karthikeyan;Nature,2022
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|