Dual PPRαϒ Agonists for the Management of Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Author:

Menezes Junior Antonio da Silva12ORCID,Oliveira Vinícius Martins Rodrigues1ORCID,Oliveira Izadora Caiado1,de Sousa André Maroccolo1,Santana Ana Júlia Prego1ORCID,Carvalho Davi Peixoto Craveiro1ORCID,Paro Piai Ricardo Figueiredo1ORCID,Matos Fernando Henrique1,de Paiva Arthur Marot1ORCID,Reis Gabriel Baêta Branquinho1

Affiliation:

1. Faculty of Medicine, Federal University of Goiás, Goiânia 74605020, Brazil

2. School of Medical and Life Sciences, Pontifical Catholic University of Goiás, Goiânia 74605050, Brazil

Abstract

Saroglitazar is a novel medication for dyslipidemia, but its specific effects remain unclear. Therefore, we performed a systematic review and meta-analysis to assess the efficacy and safety of saroglitazar for managing dyslipidemia. The PubMed, Scopus, and EMBASE databases were systematically searched for randomized controlled trials (RCTs) comparing 2 and 4 mg of saroglitazar with placebos for treating dyslipidemia. A random-effects model calculated the pooled mean differences for continuous outcomes with 95% confidence intervals. The study included seven RCTs involving 1975 patients. Overall, 340 (31.0%) and 513 (46.8%) participants received 2 and 4 mg of saroglitazar, respectively; 242 (22.11%) received the placebo. The mean ages ranged from 40.2 to 62.6 years, and 436 (39.8%) were women. Compared to the control group, 4 mg of saroglitazar significantly decreased the triglyceride and low-density lipoprotein (LDL) cholesterol levels but did not affect the high-density lipoprotein cholesterol level. Furthermore, the alanine aminotransferase level significantly decreased, the creatine level significantly increased, and body weight did not differ between the groups. Finally, 4 mg of saroglitazar, compared to 2 mg, significantly lowered the triglyceride level. Saroglitazar (4 mg) may be an effective treatment, but safety concerns remain.

Publisher

MDPI AG

Subject

General Medicine

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