Responsive Nanostructure for Targeted Drug Delivery

Author:

Pawar Vaishali1,Maske Priyanka1,Khan Amreen12,Ghosh Arnab1,Keshari Roshan2,Bhatt Mahek1ORCID,Srivastava Rohit1

Affiliation:

1. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India

2. Center for Research in Nanotechnology and Science, Indian Institute of Technology Bombay, Mumbai 400076, India

Abstract

Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that responsive biomaterials provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes in the presence of a stimulus, and that stimuli can be temperature, a magnetic field, ultrasound, pH, humidity, pressure, light, electric field, etc. Different types of stimuli being used in drug delivery shall be explained here. Recent research progress in the design, development and applications of biomaterials comprising responsive nanostructures is also described here. More emphasis will be given on the various nanostructures explored for the smart stimuli responsive drug delivery at the target site such as wound healing, cancer therapy, inflammation, and pain management in order to achieve the improved efficacy and sustainability with the lowest side effects. However, it is still a big challenge to develop well-defined responsive nanostructures with ordered output; thus, challenges faced during the design and development of these nanostructures shall also be included in this article. Clinical perspectives and applicability of the responsive nanostructures in the targeted drug delivery shall be discussed here.

Publisher

MDPI AG

Subject

Pharmacology (medical)

Reference168 articles.

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