Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species
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Published:2023-09-18
Issue:18
Volume:24
Page:14242
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Dasari Subramanyam1ORCID, Pathak Nishtha2, Thomas Amy2, Bitla Shreeja2, Kumar Raj3, Munirathinam Gnanasekar2
Affiliation:
1. School of Medicine, Indiana University Bloomington, Bloomington, IN 47405, USA 2. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL 61108, USA 3. Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, Himachal Pradesh, India
Abstract
Castration resistance poses a significant challenge in the management of advanced prostate cancer (PCa), with androgen deprivation therapy (ADT) or chemotherapy being the primary treatment options. However, these approaches often lead to significant side effects and the development of therapeutic resistance. Therefore, it is crucial to explore novel treatment options that can efficiently target PCa, improve patient survival, and enhance their quality of life. Neferine (Nef), a bioactive compound derived from plants, has emerged as a promising candidate for cancer treatment due to its ability to induce apoptosis, autophagy, and cell cycle arrest. In this study, we investigated the potential anticancer effects of Nef in androgen receptor (AR)-positive LNCaP and VCaP cells, representative models of androgen-dependent PCa. Our findings demonstrate that Nef effectively inhibits cell growth, proliferation, and the tumorigenic potential of androgen-dependent PCa cells. Furthermore, Nef treatment resulted in the excessive production of reactive oxygen species (ROS), leading to the activation of key markers of autophagy and apoptosis. These results suggest that Nef has the potential to target the oncogenic characteristics of androgen-dependent PCa cells by exploiting the potency of ROS and inducing autophagy and apoptosis in AR-positive PCa cells. These findings shed light on the therapeutic potential of Nef as a novel treatment option with reduced side effects for androgen-dependent prostate cancer. Further investigations are warranted to assess its efficacy and safety in preclinical and clinical settings.
Funder
UIC Botanical Center
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference45 articles.
1. Prostate cancer;Sandhu;Lancet,2021 2. Chemotherapy and novel therapeutics before radical prostatectomy for high-risk clinically localized prostate cancer;Cha;Urol. Oncol.,2015 3. Rayan, A., Raiyn, J., and Falah, M. (2017). Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity. PLoS ONE, 12. 4. Salehi, B., Fokou, P.V.T., Yamthe, L.R.T., Tali, B.T., Adetunji, C.O., Rahavian, A., Mudau, F.N., Martorell, M., Setzer, W.N., and Rodrigues, C.F. (2019). Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents. Nutrients, 11. 5. Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism;Dasari;Phytother. Res.,2020
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