Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer-Reference-Cited by-同舟云学术

Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer

Published:2023-08-30 Issue:17 Volume:23 Page:7527
ISSN:1424-8220
Container-title:Sensors
language:en
Short-container-title:Sensors

Author:

Ivanov Yuri D.¹^ORCID,Malsagova Kristina A.¹^ORCID,Goldaeva Kristina V.¹^ORCID,Kapustina Svetlana I.¹^ORCID,Pleshakova Tatyana O.¹^ORCID,Popov Vladimir P.²^ORCID,Kozlov Andrey F.¹,Galiullin Rafael A.¹,Shumov Ivan D.¹^ORCID,Enikeev Dmitry V.³,Potoldykova Natalia V.³,Ziborov Vadim S.⁴,Petrov Oleg F.⁴,Dolgoborodov Alexander Y.⁴^ORCID,Glukhov Alexander V.⁵,Novikov Sergey V.⁶,Grabezhova Victoria K.⁷,Yushkov Evgeniy S.⁸,Konev Vladimir A.⁹,Kovalev Oleg B.⁹^ORCID,Archakov Alexander I.¹

Affiliation:

1. Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia

2. Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia

3. Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia

4. Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia

5. JSC “Novosibirsk Plant of Semiconductor Devices with OKB”, 630082 Novosibirsk, Russia

6. Associate Printing-and-Publication Centre Technosphera, 125319 Moscow, Russia

7. JSC “Design Center for Biomicroelectronic Technologies “Vega””, 630082 Novosibirsk, Russia

8. Department for Business Project Management, National Research Nuclear University “MEPhI”, 115409 Moscow, Russia

9. Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia

Abstract

Prostate cancer (PC) is one of the major causes of death among elderly men. PC is often diagnosed later in progression due to asymptomatic early stages. Early detection of PC is thus crucial for effective PC treatment. The aim of this study is the simultaneous highly sensitive detection of a palette of PC-associated microRNAs (miRNAs) in human plasma samples. With this aim, a nanoribbon biosensor system based on “silicon-on-insulator” structures (SOI-NR biosensor) has been employed. In order to provide biospecific detection of the target miRNAs, the surface of individual nanoribbons has been sensitized with DNA oligonucleotide probes (oDNA probes) complementary to the target miRNAs. The lowest concentration of nucleic acids, detectable with our biosensor, has been found to be 1.1 × 10−17 M. The successful detection of target miRNAs, isolated from real plasma samples of PC patients, has also been demonstrated. We believe that the development of highly sensitive nanotechnology-based biosensors for the detection of PC markers is a step towards personalized medicine.

Funder

Ministry of Education and Science of the Russian Federation

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry

Link

https://www.mdpi.com/1424-8220/23/17/7527/pdf

Reference64 articles.

1. The Diagnosis and Treatment of Prostate Cancer. A Review;Litwin;JAMA,2017

2. Barani, M., Sabir, F., Rahdar, A., Arshad, R., and Kyzas, G.Z. (2020). Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates. Nanomaterials, 10.

3. MicroRNA Regulation of Androgen Receptor in Castration-Resistant Prostate Cancer: Premises, Promises, and Potentials;Ebrahimi;Curr. Mol. Pharmacol.,2021

4. Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods;Ferlay;Int. J. Cancer,2019

5. Risk Factors for Prostate Cancer: A Multifactorial Case-Control Study;Malik;Curr. Probl. Cancer,2018

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nanotechnology-based Assays for the Detection of Cancer through Sputum;Current Analytical Chemistry;2023-11