Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs

Author:

Ayechu-Abendaño Ada1,Pérez-Jiménez Aurora12ORCID,Sánchez-Matás Carmen3ORCID,López-Villalobos José Luis4ORCID,Díaz-Jiménez Cristina2,Fernández-Parra Rocío5ORCID,Malvè Mauro16ORCID

Affiliation:

1. Department of Engineering, Public University of Navarra (UPNA), Campus Arrosadía, s/n, E-31006 Pamplona, Spain

2. AIN—Asociación de la Industria Navarra, Ctra. Pamplona, 1. Edif. AIN, E-31191 Cordovilla, Spain

3. Department of Thoracic Surgery, University Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s/n, E-30120 El Palmar, Spain

4. Department of Thoracic Surgery, University Hospital Virgen del Rocío, Avenida Manuel Siurot, s/n, E-41013 Sevilla, Spain

5. Department of Small Animal Medicine and Surgery, Faculty of Veterinary Medicine, Catholic University of Valencia San Vicente Mártir, E-46001 Valencia, Spain

6. Research Networking in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, E-28029 Madrid, Spain

Abstract

The placement of endotracheal prostheses is a procedure used to treat tracheal lesions when no other surgical options are available. Unfortunately, this technique remains controversial. Both silicon and metallic stents are used with unpredictable success rates, as they have advantages but also disadvantages. Typical side effects include restenosis due to epithelial hyperplasia, obstruction and granuloma formation. Repeat interventions are often required. Biodegradable stents are promising in the field of cardiovascular biomechanics but are not yet approved for use in the respiratory system. The aim of the present study is to summarize important information and to evaluate the role of different geometrical features for the fabrication of a new tracheo-bronchial prosthesis prototype, which should be biodegradable, adaptable to the patient’s lesion and producible by 3D printing. A parametric design and subsequent computational analysis using the finite element method is carried out. Two different stent designs are parameterized and analyzed. The biodegradable material chosen for simulations is polylactic acid. Experimental tests are conducted for assessing its mechanical properties. The role of the key design parameters on the radial force of the biodegradable prosthesis is investigated. The computational results allow us to elucidate the role of the pitch angle, the wire thickness and the number of cells or units, among other parameters, on the radial force. This work may be useful for the design of ad hoc airway stents according to the patient and type of lesion.

Publisher

MDPI AG

Reference67 articles.

1. Stenting of the tracheobronchial tree;Rafanan;Radiol. Clin. N. Am.,2000

2. Outcomes of tracheobronchial stent placement for benign disease;Thornton;Radiology,2006

3. Clinic, diagnosis and treatment of tracheal stenosis;Delgado;An. PediatrÍa,2009

4. Removal of metallic tracheobronchial stents in lung transplantation with flexible bronchoscopy;Fruchter;J. Cardiothorac. Surg.,2010

5. Anatomy of the trachea, carina, and bronchi;Minnich;Thorac. Surg. Clin.,2007

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3