Author:
Flora Pooja,Dalal Gil,Cohen Idan,Ezhkova Elena
Abstract
Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and regenerating adult tissues. In addition to having the capacity to generate all the differentiated cell types of the tissue, adult SCs undergo long periods of quiescence within the niche to maintain themselves. The process of SC renewal and differentiation is tightly regulated for proper tissue regeneration throughout an organisms’ lifetime. Epigenetic regulators, such as the polycomb group (PcG) of proteins have been implicated in modulating gene expression in adult SCs to maintain homeostatic and regenerative balances in adult tissues. In this review, we summarize the recent findings that elucidate the composition and function of the polycomb repressive complex machinery and highlight their role in diverse adult stem cell compartments.
Funder
National Institute of Arthritis and Musculoskeletal and Skin Diseases
New York State Stem Cell Science
Israel Cancer Research Fund
Israel Cancer Association
Subject
Genetics (clinical),Genetics
Cited by
9 articles.
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