Zinc Status and Autism Spectrum Disorder in Children and Adolescents: A Systematic Review

Author:

do Nascimento Priscila Kelly da Silva Bezerra1,Oliveira Silva David Franciole2,de Morais Tássia Louise Sousa Augusto1,de Rezende Adriana Augusto3

Affiliation:

1. Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte—UFRN, Natal 59056-000, Brazil

2. Postgraduate Program in Collective Health, Federal University of Rio Grande do Norte—UFRN, Natal 59056-000, Brazil

3. Department of Clinical and Toxicological Analyses; Federal University of Rio Grande do Norte—UFRN, Natal 59012-570, Brazil

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, the prevalence of which has increased in children and adolescents over the years. Studies point to deficiency of trace elements as one of the factors involved in the etiology of the disorder, with zinc being one of the main trace elements investigated in individuals with ASD. The aim of this review is to summarize scientific evidence about the relationship between zinc status and ASD in children and adolescents. This review has been registered in the International Prospective Register of Systematic Reviews (registration number CRD42020157907). The methodological guidelines adopted were in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were selected from an active investigation of the PubMed, Scopus, LILACS, and Google databases to search for observational studies. Fifty-two studies from twenty-two countries were included. The sample sizes ranged from 20 to 2635, and the participants ranged from 2 to 18 years old. Nine types of biological matrices were used, with hair, serum, and plasma being the most frequently used in the evaluation of zinc concentrations. Significant differences in zinc concentrations between the ASD and control groups were observed in 23 studies, of which 19 (36%) showed lower zinc concentrations in the ASD group. The classification of studies according to methodological quality resulted in high, moderate, and low quality in 10, 21, and 21 studies, respectively. In general, we did not observe a significant difference between zinc concentrations of children and adolescents with ASD compared to controls; however, studies point to an occurrence of lower concentrations of Zn in individuals with ASD. This review reveals that more prospective studies with greater methodological rigor should be conducted in order to further characterize this relation.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference89 articles.

1. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, APA. [5th ed.].

2. Global prevalence of autism: A systematic review update;Zeidan;Autism Res.,2022

3. Hair Heavy Metal and Essential Trace Element Concentration in Children with Autism Spectrum Disorder;Tabatadze;Georgian Med. News,2015

4. Overview of inherited zinc deficiency in infants and children;Kambe;J. Nutr. Sci. Vitaminol.,2015

5. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism;Olechnowicz;J. Physiol. Sci.,2018

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