Radiological and Functional Pulmonary Evolution in Post-COVID-19 Patients: An Observational Study

Author:

Cavallari Strozze Catharin Virgínia Maria1,Zutin Tereza Laís Menegucci12,Guiguer Elen Landgraf123,Cressoni Araújo Adriano12,Fornari Laurindo Lucas14ORCID,Chagas Eduardo F. Baisi12,Gasparotti Zorzetto Cássia Fernanda1,Bueno Patrícia C. dos Santos15,dos Santos Bueno Manoela6,Cervelim Nunes Yandra3,Cavallari Strozze Catharin Vitor1,Gonzaga Heron Fernando7,Barbalho Sandra Maria123ORCID

Affiliation:

1. Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil

2. Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil

3. Department of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Avenida Castro Alves, 62, Marília 17500-000, São Paulo, Brazil

4. Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Avenida Monte Carmelo, 800, Marília 17519-030, São Paulo, Brazil

5. Department of Animal Sciences, School of Veterinary Medicine, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil

6. UNIMED Marilia-R. Bororós, 225-Sen. Salgado Filho, Marília 17502-270, São Paulo, Brazil

7. Department of Dermatology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 861, São Paulo 04025-002, São Paulo, Brazil

Abstract

COVID-19 has generated a scenario for global health with multiple systemic impairments. This retrospective study evaluated the clinical, radiological, and pulmonary functional evolution in 302 post-COVID-19 patients. Regarding post-COVID-19 pulmonary symptoms, dry cough, dyspnea, and chest pain were the most frequent. Of the associated comorbidities, asthma was more frequent (23.5%). Chest tomography (CT) initially showed a mean pulmonary involvement of 69.7%, and evaluation in the subsequent months showed improvement in the evolutionary image. With less than six months post-pathology, there was a commitment of 37.7% from six to twelve months it was 20%, and after 12 months it was 9.9%. As for most of the sample, 50.3% of the patients presented CT normalization less than six months after infection, 23% were normalized between six and twelve months, and 5.2% presented with normalized images after twelve months, with one remaining. A percentage of 17.3% maintained post-COVID-19 pulmonary residual sequelae. Regarding spirometry, less than six months after pathology, 59.3% of the patients presented regular exam results, 12.3% had their function normalized within six to twelve months, and 6.3% had normal exam results twelve months after their post-pathology evaluation. Only 3.6% of the patients still showed some alteration during this period.

Publisher

MDPI AG

Subject

General Medicine

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