Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

Author:

Salimo Zeca M.1,Yakubu Michael N.1,da Silva Emanuelle L.1,de Almeida Anne C. G.2,Chaves Yury O.3,Costa Emmanoel V.4ORCID,da Silva Felipe M. A.5ORCID,Tavares Josean F.6ORCID,Monteiro Wuelton M.12ORCID,de Melo Gisely C.12,Koolen Hector H. F.167ORCID

Affiliation:

1. Programa de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil

2. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil

3. Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus 69057-070, Brazil

4. Departamento de Química, Universidade Federal do Amazonas, Manaus 69067-005, Brazil

5. Centro de Apoio Multidisciplinar, Universidade Federal do Amazonas, Manaus 69067-005, Brazil

6. Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil

7. Grupo de Pesquisa em Metabolômica e Espectrometria de Massas, Universidade do Estado do Amazonas, Manaus 69065-001, Brazil

Abstract

Bergenin is a glycosidic derivative of trihydroxybenzoic acid that was discovered in 1880 by Garreau and Machelart from the rhizomes of the medicinal plant Bergenia crassifolia (currently: Saxifraga crassifolia—Saxifragaceae), though was later isolated from several other plant sources. Since its first report, it has aroused interest because it has several pharmacological activities, mainly antioxidant and anti-inflammatory. In addition to this, bergenin has shown potential antimalarial, antileishmanial, trypanocidal, antiviral, antibacterial, antifungal, antinociceptive, antiarthritic, antiulcerogenic, antidiabetic/antiobesity, antiarrhythmic, anticancer, hepatoprotective, neuroprotective and cardioprotective activities. Thus, this review aimed to describe the sources of isolation of bergenin and its in vitro and in vivo biological and pharmacological activities. Bergenin is distributed in many plant species (at least 112 species belonging to 34 families). Both its derivatives (natural and semisynthetic) and extracts with phytochemical proof of its highest concentration are well studied, and none of the studies showed cytotoxicity for healthy cells.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Amazonas

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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