Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation
Affiliation:
1. Department of Radiological Sciences and Medical Imaging, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia 2. Laboratory of Electronics and Microelectronics, Faculty of Science of Monastir, University of Monastir, Environment Boulevard, Monastir 5019, Tunisia
Abstract
Microwave ablation (MWA) represents one of the most powerful tools in cancer treatment. This therapeutic modality process is governed by the temperature and absorbed dose of radiation of the cell tissue. This study was performed to control the temperature effect using simulation during the MWA thermal damage of lung tumor. For this reason, a two-dimensional (2D) computational modeling generated for adaptive lung tissue was designed and analyzed using the finite element method (FEM). Different approaches, such as first-order Arrhenius rate equations, Maxwell equations, and the bioheat equation, have been used to simulate necrosis in cells. To control the heat, a proportional–integral–derivative (PID) controller was used to moderate the input microwave power source and to maintain the temperature of the target tip at a lower level of the initial temperature data. Furthermore, full cancer tissue necrosis was also evaluated by processing time and thermal damage fraction. The obtained data proved that the target tip temperature was affected by the temperature distribution and specific absorption rate (SAR). However, a specific treatment period of tumor ablation is required to control and decrease the damage of surrounding healthy tissue to ensure a safe operation without any risk.
Subject
General Physics and Astronomy
Reference51 articles.
1. Recent advances in nanotechnology-based functional coatings for the built environment;Zhu;Mater. Today Adv.,2022 2. An, C., Sun, C., Li, N., Huang, B., Jiang, J., Shen, Y., Wang, C., Zhao, X., Cui, B., and Wang, C. (2022). Nanomaterials and nanotechnology for the delivery of agrochemicals: Strategies towards sustainable agriculture. J. Nanobiotechnol., 20. 3. Subramaniyan, V., Fuloria, S., Gupta, G., Kumar, D.H., Sekar, M., Sathasivam, K.V., Sudhakar, K., Alharbi, K.S., Al-Malki, W.H., and Afzal, O. (2022). A review on epidermal growth factor receptor’s role in breast and non-small cell lung cancer. Chem.-Biol. Interact., 351. 4. Mitigating financial toxicity in breast cancer from diagnosis to treatment and reconstruction;Roy;Clin. Breast Cancer,2023 5. NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms;Beaver;Biochim. Biophys. Acta Proteins Proteom.,2019
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