Abstract
Epigenetic mechanisms are known to play a key role in cancer progression. Specifically, histone methylation involves reversible post-translational modification of histones that govern chromatin structure remodelling, genomic imprinting, gene expression, DNA damage repair, and meiotic crossover recombination, among other chromatin-based activities. Demethylases are enzymes that catalyse the demethylation of their substrate using a flavin adenine dinucleotide-dependent amine oxidation process. Lysine-specific demethylase 1 (LSD1) and its homolog, lysine-specific demethylase 2 (LSD2), are overexpressed in a variety of human cancer types and, thus, regulate tumour progression. In this review, we focus on the literature from the last 5 years concerning the role of LSD1 and LSD2 in the main gastrointestinal cancers (i.e., gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer).
Subject
Molecular Biology,Biochemistry
Reference115 articles.
1. Cancerhttps://www.who.int/news-room/fact-sheets/detail/cancer
2. International Agency for Research on Cancerhttps://gco.iarc.fr/
3. Hallmarks of Cancer: The Next Generation
4. Hallmarks of Cancer: New Dimensions
5. Epigenetic alterations in cancer
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