Collagen-Based Hydrogels for the Eye: A Comprehensive Review
Author:
Rana Dhwani1ORCID, Desai Nimeet2ORCID, Salave Sagar1ORCID, Karunakaran Bharathi1, Giri Jyotsnendu2, Benival Derajram1, Gorantla Srividya3, Kommineni Nagavendra4ORCID
Affiliation:
1. National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, India 2. Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, Telangana, India 3. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA 4. Center for Biomedical Research, Population Council, New York, NY 10065, USA
Abstract
Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical isolation and purification steps are discussed, emphasizing their pivotal role in preparing collagen for biomedical use. To ensure collagen quality and purity, and the suitability of collagen for targeted applications, a comprehensive characterization and quality control are essential, encompassing assessments of its physical, chemical, and biological properties. Also, various cross-linking collagen methods have been examined for providing insight into this crucial process. This comprehensive review delves into every facet of collagen and explores the wide-ranging applications of collagen-based hydrogels, with a particular emphasis on their use in drug delivery systems and their potential in diverse biomedical interventions. By consolidating current knowledge and advancements in the field, this review aims to provide a detailed overview of the utilization of engineered collagen-based hydrogels in ocular therapeutics.
Funder
National Institute of Pharmaceutical Education and Research—Ahmedabad (NIPER-A), the Department of Pharmaceuticals, the Ministry of Chemicals and Fertilizers, and the Government of India Department of Science and Technology, the Ministry of Science and Technology, the Science and Engineering Board, India Abdul Kalam Technology Innovation National Fellowship Indian National Academy of Engineering, India
Subject
Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering
Reference124 articles.
1. Parenteau-Bareil, R., Gauvin, R., and Berthod, F. (2010). Collagen-Based Biomaterials for Tissue Engineering Applications. Materials, 3. 2. Biomedical Applications of Collagen;Lee;Int. J. Pharm.,2001 3. Jafari, H., Lista, A., Siekapen, M.M., Ghaffari-Bohlouli, P., Nie, L., Alimoradi, H., and Shavandi, A. (2020). Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering. Polymers, 12. 4. Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues;Song;Front. Surg.,2021 5. Polysaccharide Based Implantable Drug Delivery: Development Strategies, Regulatory Requirements, and Future Perspectives;Salave;Polysaccharides,2022
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|