Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders

Author:

Tan Zhengye,Li Wen,Cheng Xiang,Zhu Qing,Zhang XinhuaORCID

Abstract

Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities—such as development, neurogenesis, degeneration, and the response to injury to the nervous system—via protein translation, RNA splicing, gene activation, silencing, modifications, and editing; thus, they may serve as potential targets for disease treatment. The activity of adult neural stem cells (NSCs) in the subgranular zone of the hippocampal dentate gyrus critically influences hippocampal function, including learning, memory, and emotion. ncRNAs have been shown to be involved in the regulation of hippocampal neurogenesis, including proliferation, differentiation, and migration of NSCs and synapse formation. The interaction among ncRNAs is complex and diverse and has become a major topic within the life science. This review outlines advances in research on the roles of ncRNAs in modulating NSC bioactivity in the hippocampus and discusses their potential applications in the treatment of illnesses affecting the hippocampus.

Funder

National Natural Science Foundation of China

Jiangsu Natural Science Foundation

Jiangsu ‘333’ program funding

the Application Research Project of Nantong City

the Training Program of Innovation and Entrepreneurship for Graduates

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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