Abstract
Supramolecular combination therapy adopts supramolecular materials to design intelligent drug delivery systems with different strategies for cancer treatments. Thereinto, macrocyclic supramolecular materials play a crucial role in encapsulating anticancer drugs to improve anticancer efficiency and decrease toxicity towards normal tissue by host–guest interaction. In general, chemotherapy is still common therapy for solid tumors in clinics. However, supramolecular combination therapy can overcome the limitations of the traditional single-drug chemotherapy in the laboratory findings. In this review, we summarized the combination chemotherapy, photothermal chemotherapy, and gene chemotherapy based on macrocyclic supramolecular materials. Finally, the application prospects in supramolecular combination therapy are discussed.
Funder
Beijing Natural Science Foundation
National Natural Science Foundation of China
Subject
Polymers and Plastics,General Chemistry
Reference122 articles.
1. Teixeira, S., Carvalho, M.A., and Castanheira, E.M.S. (2022). Functionalized liposome and albumin-based systems as carriers for poorly water-soluble anticancer drugs: An updated review. Biomedicines, 10.
2. Toxicities of anticancer drugs and its management;Int. J. Basic Clin. Pharmacol.,2012
3. Wadhawan, A., Chatterjee, M., and Singh, G. (2019). Present scenario of bioconjugates in cancer therapy: A review. Int. J. Mol. Sci., 20.
4. Polymers in the co-delivery of siRNA and anticancer drugs for the treatment of drug-resistant cancers;Polymeric Gene Delivery Systems,2017
5. Clinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs;Wires Nanomed. Nanobiotechnol.,2013
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