Abstract
Characterized by cardiovascular disease and diabetes, cardiometabolic diseases are a major cause of mortality around the world. As such, there is an urgent need to understand the pathogenesis of cardiometabolic diseases. Increasing evidence suggests that most of the mammalian genome are transcribed as RNA, but only a few percent of them encode for proteins. All of the RNAs that do not encode for proteins are collectively called non-protein-coding RNAs (ncRNAs). Among these ncRNAs, long ncRNAs (lncRNAs) are considered as missing keys to understand the pathogeneses of various diseases, including cardiometabolic diseases. Given the increased interest in lncRNAs, in this study, we will summarize the latest trend in the lncRNA research from the perspective of cardiometabolism and disease by focusing on the major risk factors of cardiometabolic diseases: obesity, cholesterol, diabetes, and hypertension. Because genetic inheritance is unavoidable in cardiometabolic diseases, we paid special attention to the genetic factors of lncRNAs that may influence cardiometabolic diseases.
Subject
Genetics (clinical),Genetics
Reference123 articles.
1. Yang, T., Yi, J., He, Y., Zhang, J., Li, X., Ke, S., Xia, L., and Liu, L. (2022). Associations of Dietary Fats with All-Cause Mortality and Cardiovascular Disease Mortality among Patients with Cardiometabolic Disease. Nutrients, 14.
2. The regulatory network architecture of cardiometabolic diseases;Schmidt;Nat. Genet.,2022
3. Association, T.H. (2022, December 09). HjerteTal.dk. Available online: www.hjertetal.dk.
4. Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association;Musunuru;Circ. Genom. Precis. Med.,2020
5. Family history of cardiovascular disease;Kolber;Can. Fam. Physician,2014